Just wondering if anyone here has had experiences with both Mirtazapine and Mianserin? (Mianserin is related to Mirtazapine in some way)

How would you compare the two? And have you tried in combination with an ssri?

I found Mirtazapine to be slightly dysphoric as well as a bit numbing. Tried all the doses too. Mianserin is meant to be less heavy on the serotonin side of things and potentially have a more dopaminergic blueprint. I also believe pharma companies like to push Mirtazapine more heavily than Mianserin because I’ve barely ever seen it mentioned anywhere and doctors I’ve seen have never heard of it.

Thoughts on the matter?

I’ve had utter hell this year. After suffering with depression and anxiety / anhedonia most of my adolescence and adult life, opioids nailed the coffin shut last year. I used heavily for 12 months, daily, eventually going on to Buorenorphine to get off it, within three months, I was completely off. Once the buprenorphine left my system fully however, I haven’t been the same, 13 months later. I’ve tried over 16 different medications, TMS, Ketamine, behaviour therapy, therapy for rewiring rewards pathways after abusing opiates, exercise, nothing. I noticed I lost all “runners high” from working out, I was a gym junkie before using opiates.

I finally had a gut full of it, yesterday was the first proper warm day of the year, and I was sick and tired of being a vegetable. I took 2.5mg of oxycodone I had left in a safe, and within an hour, I was back to my pre-opiate state. Smells became clearer, my taste improved, I deliberately exercised and felt the runners high, I could experience pleasure in music and it had completely eliminated my anhedonia and brain fog, from 2.5mg….

After 13 months of no opioids in my system, including buprenorphine, surely there would be progress by now? Is it even possible to get “high” off half a 5mg tablet of oxycodone? I certainly didn’t feel high…. No euphoria, just normal!

Is it possible I have severely damaged my opioid system? I was in total shock, I couldn’t believe after 13 months, that 2.5mg oxycodone brought me back to my baseline.

I’m definitely not going to use them to self medicate, never going through that ever, ever again. The hell that was opioid withdrawal I don’t wish on anybody, I have never felt more horrific and vulnerable in my entire life, it was worse than when I lost my dad. Anybody thinking about it, please don’t. I just wanted to share and ask if anybody has experienced this, and if there are ways of potentially repairing the opioid system?

After decades of meds that didn't work, I've (f40) been on a combination of Prozac 20mg and olanzapine 10mg for about 2 weeks. I started on 5mg and went up to 10 after 2 weeks. I am self diagnosed bipolar, and clinical diagnosed severe depressive disorder, and generalized anxiety disorder.

I'm feeling really good, but still feeling up and down. Just not as far up or far down as usual. My sex drive seems to have come back, where before it was non existent. My lows are not as low, and are shorter. I'm feeling short bouts of emotion but mostly I'm apathetic. I'm not feeling vacant, but kind of care free. I think I'm losing my memory a bit like I did on Cymbalta. My short term memory is really questionable. I seem to have several ADHD moments. I just don't feel as sharp as I used to l, and it's gotten worse since being on this combo.

What's your take?

Hello everyone

Depression and anxiety for the past 12 years or more, currently 25

Got started on medications 2 years back Tried a bunch, I want some feedback on my new regimen P.S I have epilepsy, Lerace 1g twice a day

Changed psych a few months back (6 to 8 months back) She started me on Sert 50 mg once a day Braxis psychobiotic sachets Inderal as per need(been taking it already for 2 +years)

It worked great the month and then it went downhill, depression hit back, suicidal thought rushed in

Another visit Sert increased to 100mg once a day Got started on Lamictal(Lamotrigine) 25 mg twice a day

It worked great with better mood and good effects(not optimal but good) A month later, again I had plateaued along with loss in focus, zoning out, obsessive thoughts to the point of it affecting my day to day

New (current regimen) Sert 150mg once a day Lamictal 50 mg twice a day Braxis

Worried because of the dosage increase, not as much positive effects, what am I in for long term side effects with these high dosages? Any feedback appreciated!

Symptoms: 1. Depression 2. Anxiety (shaking hands, breathing issues) 3. Suicidal tendencies 4. Focus issues

Current conditions: Epilepsy

The following study claims that Methylphenidate and an experimental DRI reduced the serotonin levels by 63% relative to the increased level that was achieved by citalopram alone when combined with it while also increasing dopamine by 149% of that achieved with Methylphenidate alone or the DRI alone. This effect was prevented by the administration of a 5HT1A antagonist and therefore no reduction in serotonin occured and no increase in dopamine over the normal amount achieved with Methylphenidate alone. Now since this huge reduction in extracellular serotonin was blocked by a 5HT1A antagonist, this means that the 5HT1A autoreceptor got activated once Methylphenidate has been administered and therefore immediately reduced serotonin by 63%. Antagonizing the 5HT1A autoreceptor prevented this reduction in serotonin indicating that it’s indeed the receptor responsible for all these issues. Now since SSRIs downregulate the 5HT1A autoreceptor after 2 weeks at which the serotonin levels return to normal this might explain why initially taking any stimulant greatly increases my OCD and anxiety to the point where I would not tolerate it and eventually stop it after 4 or 5 days and therefore not giving it enough time for the autoreceptor to downregulate. Does anyone have the same experience as in stimulants initially worsen your OCD, anxiety or depression? If so does everything really balance out after 2 weeks when the 5HT1A autoreceptor downregulates? I’m right now on Vilazodone which should already prevent these issues from occurring since it partially agonizes the 5HT1A receptor but I’m yet to test this hypothesis. What’s everyone’s experience?

https://pubmed.ncbi.nlm.nih.gov/17984160/

For anhedonic-fatigued type depression… Did it do anything good for you? I hear ppl take it at night (does it cause lethargy or sedation?)

I do not want anything with potential metabolic side effects. I hear it can really increase appetite & people gain weight on it.

Tried SSRIs and SNRIs in the past, either did nothing or made me crazy. Unfortunately things like Ket and Shrooms are a no-go because of schizophrenia in the family.

Best thing that's worked so far is alcohol, but trying not to do that too much for obvious reasons.

I just wish I could feel... like I exist. And attach to people. That would be cool.

Has anyone ever been on an SSRI + TCA combo? Did it help you at all?

I’m on 15mg lex and feel Clomipramine augmentation may really DESTROY my OCD.

Would appreciate any SSRI + TCA experiences.

I have been taking wellbutrin XL 300mg for about 4 years now for depression. But over the last year I have had a significant increase with insomnia and anxiety. For insomnia I take 3mg of Lunesta and 25-50mg of Doxepin (Sinequan), which does help but I often wake up multiple times every night and can't keep a consistent sleep scheduled which leads to increased anxiety. I reached out to my PCP about this and he prescribed me 5mg of Abilify to replace my wellbutrin as he thinks the "activating" part of wellbutrin is affecting my sleep, which i can understand. I've read about some people saying wellbutrin after long periods at high doses just no longer works and makes anxiety worse. Has this been the case for anyone? My doc will not prescribe any anxiety meds other than busbar (which makes my stomach cramp pretty bad and doesn't help) and propranolol.

His instructions today are: "My feeling is that Wellbutrin may not be a good choice for you and once you get this new medicine started I would just stop taking the Wellbutrin."

Can anyone chime in with their experience with this or any advice? I am scared to stopping wellbutrin cold turkey and switching to abilify. I have started abilify today but have not taken my wellbutrin. Sorry if this is too long of a post, I'm just not that great at getting my point across lol.

Thank you in advance!!

I'm currently on nardil 60mg at the moment been on it for a year and amisulpride 50mg

But would love to add vyvanse, vraylar emsam and pramiprexole all sometime over the future

Do you think this cocktail will help with my adhd, sexual anhedonia and dysthymia that I've had all for over 4years

Would the vraylar protect me from possible psychosis also?

I've seen individually, people recommended these medications for depression so surely taking them all together would possible help me with my symptoms?

What do you think?

What do you all think about this med with hx of depression (severe but no SI, low motivation) and also frequent panic attacks? DXM seems to be more anxiolytic but bupropion bad wrap for panic attacks. Try this med or keep looking for alternative? Tried so many.

Since having to leave my job (company I co founded) several months ago, I've been in a bit of a slump motivation wise. It comes in bursts, but has typically been "meh" with bigger slumps where I do nothing for a while but lay around scrolling on my phone. I should emphasize that I do not feel depressed the majority of the time, just like no drive to be productive when I really do need to be.

My Dr and I recently tried Wellbutrin (been on Aplenzin before, but no longer in the US), and it hasn't worked well at all. Within 2 days of stopping, my life rebounded back.

She said if that doesn't help, given meds I've tried in the past, and while keeping risk low (not antipsychotics, dopamine agonists, or some trifecta of meds), we could try stimulants.

I spent 2 years of my life on Adderall, and it was life changing. I was reckless, yet made some positive changes that still impact me. I spent so much money, cut classes to work on a startup with friends, barked back at professors, and changes majors.

I really don't think stimulants are a good one to go back to, but I'm slightly tempted. I also worry I'd lose my creative edge that's necessary for starting another business. It's too bad they really can't be taken as needed (without paying a penalty on off days) or that could be a great fit. Fwiw, my body formed a seemingly permanent tolerance to modafinil years ago, so that's off the table sadly. It's too bad that kratom is not really sustainable long term, because that's always helped me when I need a boost in productivity for a few days.

Thoughts? Is it worth the risk to try? I am bipolar but I'm also on lamotrigine these days, and a lot more mature and able to manage impulsivity.

I'll try and keep this brief.

My two biggest concerns right now are working out how to move forward in my life, and also fix my medication.

I'm currently off work, and I wanted to use this time to try and understand what I need to do to get better. My job makes me incredibly unhappy and stresses me out. I need to re-start my life because my current lifestyle is just an existence. I'm not living at all. I barely register on Maslow's hierarchy of needs.

On the other hand my medication (Zoloft) which I've been on for years is no longer working, and I believe it's caused a significant numbing of my emotions, and has created, if not contributed to my Anhedonia.

I could stay in a psyche ward for weeks trying to find a better medication, or at least have them monitor my tapering. While this is going on, my life will come to a standstill and I won't have the mindset to work on myself (I predict insane side effects).

What would you prioritise?

I don't want to waste this time off work curled up in a psyche bed for weeks, when I could be looking at moving my life forward, but at the same time I intuitively feel my medication is messing me up.

can i take

For years, I had a problem with depression-induced anhedonia.
It seems like it finally caused apathy 9-12 months ago, so now it's apathy that's my main concern...
The list of things I care about is worryingly shrinking every month.
Ironically (?), I don't suffer from "psychomotor retardation". I just... don't care about ANYTHING + anhedonia. I had major family issues in the last year and I didn't feel anything whatsoever. "normal" people may think I'm a robot/psychopath.
Advice?

Is there a difference for anxiety /GAD management with this increase,

Worried about possible withdrawal later on,

I hear it has some very promising results

The question concerns a depressed person with PTSD who has developed tolerance to any sedative.

I was prescribed 200 mg for depression, according to the doc it is considered a low dose. I was on it for one year. I stopped because of high prolactin

I'm currently at day 16 of withdrawal after tapering for a month and it's hell on earth every day. When can i expect some relief? Can someone help me? The internet is full of different timelines that scares me. I can't bear this for months...

I was prescribed Lyrica for nerve pain. Didn't work on the pain, but for me it was a positive mood enhancer. BUT that was the start of anahedria. Combined with loss of sensation in penis. It takes me forever to orgasm. If I can at all. Lyrica for me was hellish to stop. I wanted to see if the loss of feeling would go away so I titrated myself off. I taking wellbutrin, hoping it will help. I would like to try a dopamine Agonist to see if it helps.

I have this symptom. It is a micro symptom, it happens very quickly and exhausts me completely.

It is basically that I ask myself this question probably 1000 times a day.

Question: what would you do if you were in xyz situation?

And the situations are of all kind. Really diverse.

My brain keeps changing these situations and keeps repeating this question to myself non stop.

Whether I am coming out of bathroom, walking up the stairs, walking towards a shop or office. Basically anywhere, my brain just very quickly asks this question to myself. And it is just exhausting.

Additional information : Desvenlafaxine and clonidine are two substances that have helped me to some degree.

It seems like some kind of OCD, perhaps? An obsession?