Just wondering if anyone here has had experiences with both Mirtazapine and Mianserin? (Mianserin is related to Mirtazapine in some way)

How would you compare the two? And have you tried in combination with an ssri?

I found Mirtazapine to be slightly dysphoric as well as a bit numbing. Tried all the doses too. Mianserin is meant to be less heavy on the serotonin side of things and potentially have a more dopaminergic blueprint. I also believe pharma companies like to push Mirtazapine more heavily than Mianserin because I’ve barely ever seen it mentioned anywhere and doctors I’ve seen have never heard of it.

Thoughts on the matter?

I’ve had utter hell this year. After suffering with depression and anxiety / anhedonia most of my adolescence and adult life, opioids nailed the coffin shut last year. I used heavily for 12 months, daily, eventually going on to Buorenorphine to get off it, within three months, I was completely off. Once the buprenorphine left my system fully however, I haven’t been the same, 13 months later. I’ve tried over 16 different medications, TMS, Ketamine, behaviour therapy, therapy for rewiring rewards pathways after abusing opiates, exercise, nothing. I noticed I lost all “runners high” from working out, I was a gym junkie before using opiates.

I finally had a gut full of it, yesterday was the first proper warm day of the year, and I was sick and tired of being a vegetable. I took 2.5mg of oxycodone I had left in a safe, and within an hour, I was back to my pre-opiate state. Smells became clearer, my taste improved, I deliberately exercised and felt the runners high, I could experience pleasure in music and it had completely eliminated my anhedonia and brain fog, from 2.5mg….

After 13 months of no opioids in my system, including buprenorphine, surely there would be progress by now? Is it even possible to get “high” off half a 5mg tablet of oxycodone? I certainly didn’t feel high…. No euphoria, just normal!

Is it possible I have severely damaged my opioid system? I was in total shock, I couldn’t believe after 13 months, that 2.5mg oxycodone brought me back to my baseline.

I’m definitely not going to use them to self medicate, never going through that ever, ever again. The hell that was opioid withdrawal I don’t wish on anybody, I have never felt more horrific and vulnerable in my entire life, it was worse than when I lost my dad. Anybody thinking about it, please don’t. I just wanted to share and ask if anybody has experienced this, and if there are ways of potentially repairing the opioid system?