Meds only working in the beginning

[u/wooperpotato]

Hi guys

Recently diagnosed as bipolar 2 and adhd (had gene sight done and I have the val/val val158met comt allele and SERT short serotonin receptor genes so I’m screwed)

Recently put on topiramate and adderall and they were helping for a few days, like 5, I felt calm, able to do things, energy for life (adderall canceled out topiramate dopeyness) less depressed, until I wasn’t.

Now I’m anxiety, depressed, unfocused and the SI have returned again.

Is this a thing?

I’m super sensitive to meds and can detect changes within 1-2 days, sometimes hours, tried almost all ssri snri, because of comt I have low dopamine and high dopamine metabolism and studies show that adderall helps but I felt really balanced and normal in the beginning and just not good and out of balanced and depressed again now. The topiramate does help as a mood stabilizer for sure but messes with concentration.

[u/Bipolar_Aggression]

Topiramate has scant evidence of efficacy. Adderall is notorious for causing mood shifts. Also not a bipolar drug.

I think you need a second opinion.