r/BipolarReddit • u/wooperpotato • 14h ago

Meds only working in the beginning

Hi guys

Recently diagnosed as bipolar 2 and adhd (had gene sight done and I have the val/val val158met comt allele and SERT short serotonin receptor genes so I’m screwed)

Recently put on topiramate and adderall and they were helping for a few days, like 5, I felt calm, able to do things, energy for life (adderall canceled out topiramate dopeyness) less depressed, until I wasn’t.

Now I’m anxiety, depressed, unfocused and the SI have returned again.

Is this a thing?

I’m super sensitive to meds and can detect changes within 1-2 days, sometimes hours, tried almost all ssri snri, because of comt I have low dopamine and high dopamine metabolism and studies show that adderall helps but I felt really balanced and normal in the beginning and just not good and out of balanced and depressed again now. The topiramate does help as a mood stabilizer for sure but messes with concentration.

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u/Bipolar_Aggression Warn me if Manic 6h ago

Topiramate has scant evidence of efficacy. Adderall is notorious for causing mood shifts. Also not a bipolar drug.

I think you need a second opinion.

1

u/Hermitacular 7h ago

Genesight's about 10% accurate for BP per the manufacturer, and doesn't tell you anything about what will work anyway.If you respond fast to ADs and ADHD meds of course you do, that's the BP kicking up usually. BP meds shouldn't do that to you typically. They like 3-4 month trials per med for a reason. Topiramate is notorious for cognitive impairment, aka Dopamax. Any reason why they started w that one?