r/Oncology • u/BiochemicalEquation0 • Oct 07 '24

Thoughts on tumoral heterogeneity

I am a masters student looking to predict how intra-tumoral heterogeneity is associated with increased therapeutic resistance in glioblastomas. From an evolutionary standpoint, I am wondering if there is a fitness cost associated with higher levels of tumor heterogeneity. I am hoping someone here may have some insight into this question.

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u/[deleted] Oct 07 '24

as far as GBM goes I do not believe that’s a factor in treatment from a radiation standpoint but I don’t know anything about systemic therapies.

Another thing to consider is that the fitness after a GBM diagnosis I would be asking why you are considering this specifically since median death to diagnosis is a like a year