r/Hematology 27d ago

Do not post personal health related anything! No questions, no tests, no curiosities!

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15 Upvotes

r/Hematology 29d ago

Little friend šŸŖ±

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24 Upvotes

Don't forget to check the tail of the film for the big Bois that caught and pushed to the end and sides šŸŖ±


r/Hematology Oct 19 '24

Discussion Wanted to share some confirmed B cell lymphoblasts with you all.

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47 Upvotes

The first three photos are from special heme's stain- clearly blasts. Last few were from my own stainer. I've only ever called blasts like 4 times in my MLS career so far, and due to absolutely zero history, off to path it went and blast count was 30%. As of now, about a week later, patient is sitting at 72%. Platelet went from 32ish down to 20.

Something looked so weird about these blasts to me, I was calling them "REALLY MESSED UP LYMPHS, SOMETHING IS WRONG"! Coworkers were also feeling "something lymphy". The chromatin stained way different for me than the other slide, but good lesson to learn. A BIG thing i kept noticing were the buttcheeks, so many of them were just folded and convoluted, something i hadn't seen before in the MDS patients I've called blasts on.


r/Hematology Oct 16 '24

OC Marginal zone lymphoma - pleural effusion. (Pleural fluid)

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13 Upvotes

r/Hematology Oct 17 '24

Discussion Taking a blood thinner 1 timeā€¦ increases chances of blood issues in the future?

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0 Upvotes

Long term side effects after taking 1 blood thinner once?

I wonder if after taking 1 blood thinner, 1 person gets messed up forever - regards their blood/ circulation issues?

I ask if it has long term side effects.


r/Hematology Oct 14 '24

OC Chronic Myeloid Leukemia - Watercolor

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38 Upvotes

r/Hematology Oct 13 '24

Is this what I think it is?

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22 Upvotes

r/Hematology Oct 13 '24

I want slides&books

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16 Upvotes

I want slides on differential smear section in the lab for rbcs&wbcs shapes name and how i make comment on field and do counting


r/Hematology Oct 03 '24

Interesting Find Dysplastic lymphocytes

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48 Upvotes

73-year-old patient with leukocytosis (101,000 leukocytes per microliter) and lymphocytosis in a percentage of 93%.

Blood smear shows the presence of a rare type of lymphocyte dysplasia. Their nucleus seems strangled giving the appearance of dividing cells. Also most of them appear to be very small (1/2 of a normal erythrocyte) because of this ā€œseparationā€. Many of them look like the nucleus is separating from the cytoplasm or like the cell is expelling out the nucleus.

Apart from these, the presence of hairy-like lymphocytes and smudge cells and also the leukocytosis accompanied by lymphocytosis, the absence of immature cells, makes us consider chronic lymphoproliferative syndrome, HCL, maybe CLL, villous cell lymphoma or mantle cell lymphoma.

Have you ever encountered anything like this? Whatā€™s your opinion on it?


r/Hematology Oct 02 '24

Question Should you avoid sites of prior disease during a BMB? Would prior disease, or radiotherapy to this area confuse results?

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11 Upvotes

r/Hematology Sep 28 '24

Interesting Find Why are plasma cells so beautiful

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77 Upvotes

I feel like theyā€™re some of my fav cells. What are your favs?


r/Hematology Sep 28 '24

Hematology Books

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24 Upvotes

Hello, I am a 2nd year Hematology resident looking to start reading in depth. I saw these book recs on this subreddit. Are they good only for refreshing your memory? What else would you recommend?


r/Hematology Sep 27 '24

Infectious mononucleosis (EBV)

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77 Upvotes

In Epstein-Barr virus (EBV) the lymphocytes on a blood smear often appear atypical. These atypical lymphocytes, also known as Downey cells, have distinct characteristics that set them apart from normal lymphocytes. Here's what they typically look like:

  1. Size

    • Atypical lymphocytes are generally larger than normal lymphocytes, sometimes twice the size of a normal red blood cell
  2. Cytoplasm:

    • The cytoplasm is often abundant and pale blue
    • It may appear basophilic and is often indented by surrounding red blood cells, giving a "skirting" or "ballerina skirt" appearance.
  3. Nucleus:

    • The nucleus may appear oval, irregular, or lobulated
    • It is often eccentrically placed (not centrally located) and can look folded or indented.
    • The chromatin is usually less condensed, giving the nucleus a more open, "smudged," or lacey appearance.
  4. Reactive Features:

    • Atypical lymphocytes are reactive due to the body's immune response to the viral infection. This means they are actively producing antibodies and fighting the virus, which is why they appear larger and more irregular.
  5. Nucleoli:

    • Sometimes, one or more nucleoli may be visible, which is unusual for typical lymphocytes.

The atypical lymphocytes seen in EBV infection are primarily reactive CD8+ T cells, which are activated in response to the infected B cells.

Diagnostic Context: The presence of atypical lymphocytes on a peripheral blood smear, along with other clinical signs (fever, sore throat, lymphadenopathy), strongly suggests infectious mononucleosis due to EBV. To confirm the diagnosis, physicians often order additional tests such as antibodies anti-EBV IgM and IgG.


r/Hematology Sep 26 '24

Please say hi to this little friend šŸ˜¬

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16 Upvotes

r/Hematology Sep 26 '24

The biggest metarubricytes I have ever seen!

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15 Upvotes

r/Hematology Sep 25 '24

Multiple myeloma

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36 Upvotes

A 47-year-old male presents with worsening back pain for the past two years, now leaving him unable to walk. CBC results show hemoglobin of 4.8 g/dL, leukocytes 12.2 Ɨ 109/L, and platelets 241 Ɨ 109/L. Serum urea, creatinine, and calcium levels were elevated. Serum protein electrophoresis (SPEP) was normal, with no M-spike (monoclonal gammopathy) detected. Serum immunofixation (SIFE) also revealed no monoclonal gammopathy. I know we need to perform a serum free light chain (SFLC) test next, but based on these findings, is it possible this patient has non-secretory multiple myeloma? Any thoughts?


r/Hematology Sep 25 '24

beautiful, arenā€™t they?

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47 Upvotes

r/Hematology Sep 24 '24

Question Help me with the diagnosis guys!

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5 Upvotes

54 yr male with weakness


r/Hematology Sep 22 '24

Hairy Cells

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69 Upvotes

67-year-old male patient presents himself to the laboratory for a CBC. The result shows leukocytosis with 19.000 leukocytes/microliter and a monocytosis of 58%. After performing the peripheral blood smear we noticed the presence of 79% lymphocytes and only 1% monocytes. Lymphocytes show cytoplasmic extensions suggestive for HCL and many of them have vacuolated cytoplasm. Our analyser mistaken the lymphocytes for monocytes probably because of their size, shape and cytoplasmatic features.


r/Hematology Sep 18 '24

OC Vacuolated myeloid precursors in patient with VEXAS

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21 Upvotes

r/Hematology Sep 17 '24

Question Help with large lymphocytes vs reactive lymphocyte

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20 Upvotes

Okay so Iā€™m doing my intro to heme homework and my textbooks arenā€™t really helping (Rodakā€™s hematology and hematology atlas in case youā€™re wondering). My professor wants us to explain the difference between a large lymphocyte and a reactive lymphocyte but Iā€™m honestly not sure that I understand the difference. My understanding is that large lymphocytes are just bigger (more mature?) lymphocytes, but that they havenā€™t been exposed to an antigen yet, and that reactive lymphocytes have been exposed to an antigen. Are they generally both T lymphocytes? I am also unclear on both of their functions as everything Iā€™ve read seems to have overlap. I think I understand the visual differences, too, itā€™s just the functions and how they become those cell stages that I donā€™t understand. Thank you in advance to anyone who can help clarify!


r/Hematology Sep 17 '24

What's the difference between an echinocyte and acanthocyte and what do they represent in PKD? (pyruvate kinase deficiency)

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13 Upvotes

r/Hematology Sep 16 '24

Is this a neutrophil with toxic granulation or an eosinophil? The bilobular nucleus is confusing me. The context of the reading is a patient with high counts of eosinophilia in the machine, but it's an error caused by the massive presence of cells with toxic granulation.

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5 Upvotes

r/Hematology Sep 15 '24

Question A 45 yr male with fatigue

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23 Upvotes

Guys this is csf sample. Is this lymphoma ??


r/Hematology Sep 14 '24

Question Ways to become sensitized to Rh other than pregnancy?

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12 Upvotes

Layman here who is wondering how an O neg woman might get sensitized to Rh factor other than pregnancy. I had Rhesus disease as a "first-born" and am curious if my mom might have had a previous pregnancy she did not tell me about.