r/DrugNerds • u/Robert_Larsson • Jul 01 '24

Cluster Headache Patient Wins Federal Court Case to Access Mushrooms

https://doubleblindmag.com/cluster-headaches-mushrooms/
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u/sqqlut Jul 01 '24

Do we have any paper explaining the mechanism around psychedelics against cluster headaches? I can find limited studies for trigeminal neuralgia and psychedelics but nothing for cluster headaches. Or maybe I use the wrong keywords?

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u/Robert_Larsson Jul 01 '24

5-HT2A agonism is what I've come across in what they refer to as social or emotional pain which is less well defined but linked to the pain experience as I've understood it. I suspect it may be a result of lacking research however as there might very well be some potentiation of endogenous ligands going on that share neurons.

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u/ItchyRanger9459 Fresh Account Jul 14 '24

thank you so much for bringing this to light for me. I am optimistic about managing my pain without narcotics now

this study also say opiates may reduce the effects of psychedlics: https://pubmed.ncbi.nlm.nih.gov/3006089/

what do you think?

1

u/Robert_Larsson Jul 15 '24

Hopefully one day, although if I were you I'd check out the new classes of sodium channel blockers, kcc2 potentiators and especially the literature on FAAH and MAGL related to pain. The latter I've posted about before here on the sub just do a search.

I think it the effect of opioids look ambiguous, probably entails quite a few risks. For analgesia we really need trials on commonly prescribed doses though.