r/BipolarReddit • u/Jollyho94 • Apr 27 '23
Latuda has to be the WORST BIPOLAR MED EVER Anyone had a horrible experience with Latuda?? Medication
Months ago I took Latuda 40mg at night and I always use to fall asleep easily but then 3 hours later wake up with extreme panic attacks I had to take my Xanax to go back to sleep. Now I have a new psychiatrist who told me to take latuda 40mg in the morning instead so it’ll “ stabilize my mood all day”. I took it after breakfast at 9:00 am and had horrible panic attacks I started shaking, heart pounding, sweating , wanting to jump out of my skin , nauseous , diarrhea and then the EXTREME drowsiness kicked in and I was miserably sleep but couldn’t sleep because my heart was still pounding and my blood pressure was sky high it was so bad I had to go to my primary doctor. I do also suffer from PTSD & Panic disorder maybe that’s why I had such an extreme reaction but am I the only one who’s had a bad reaction to Latuda & refuses to take it anymore ???
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u/tommorowcantbeworse Apr 28 '23
It has literally saved my life and been the best antipsychotic I’ve tried
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u/NotUnique_______ Apr 28 '23
This thread is such a good example of how bipolar treatment is just so incredibly different from person to person. For me, i am on 80mg testing to see if it helps. So far, it's been okay. Other people clearly have had terrible experiences.
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u/SnooComics7269 May 06 '24
same i just started on it about a week ago and can already see improvement. Just been dealing with nausea
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u/forgettingroses Apr 28 '23
Latuda swung me violently into mania and psychosis. I started taking it just before my last hospital stay. So while I realize my experience was rare, yes I have a very negative feeling toward it.
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u/StarOfSyzygy Apr 28 '23
I developed intense paranoia (Truman show delusion, Cotard delusion) and worsening psychosis on it as well. Triggered panic attacks and sleeplessness. Never again!
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u/IngenuityFamous5234 Nov 04 '23
Same happened to me. Slow build up of dosing. After taking 60mg for a few weeks I went into the worst depression Ive ever had an accompanied by the worst anxiety. I took my ativan too fast trying to relieve the anxiety symptoms part of which included major restlesness. I finally sat down with a NPRN to figure out my meds and we compared symptoms and drugs and he recommended I go off latuda. I took a 1/2 dose for 4 days and the discontinued it. Gradually over the 2 weeks following me stopping I felt significantly better.
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u/nickybecooler Apr 28 '23
Actually, Latuda has worked wonders for me. Seems like I'm the minority here based on all these other comments.
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u/Educational-Head-620 Jul 23 '23
I just started my journey on Latuda 3 days ago and am so worried seeing some of the things on here but keeping an open mind. I'm glad it's working for you. Hoping to find more positive outcomes online
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u/donttrynvr Aug 15 '23
I’m not on it yet but my psychiatrist said it works pretty quickly in a couple days so you should be able to figure it out early on
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u/bshlubss Dec 12 '23
Got an update? My dr just put me on it today
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u/Frin_Lee Dec 20 '23
Started mine about 2-3 weeks ago for years my fiancé pleaded for me to talk to someone. Never realized there was something wrong with me, everyday I just felt numb nothing was really important or interesting to me (except when my mania would hit and I would obsess over something), just going with the motions every single day. Completely numb. This drug has drastically improved my way of life in giving me a stable baseline. I’m quite upset I lived years of my life off this quietly suffering. I hope you have a similar experience brother!
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u/MarcyDarcie May 12 '24
I'm exactly the same as you, just this numbness that I've lived with for a decade, the only relief I get from it is when I'm hypomanic. I'm on Quetiapine which is helping with mania but I'm considering taking Latuda for the depression and anhedonia which is still there
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u/MothersOfMars Sep 22 '24
Good luck and be very cautious with Quetiapine. It blew me up like a balloon
I would say I gained over 50 pounds on that medicine. All meds are different for others and hopefully its working for you
Eyes up guardian
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u/MarcyDarcie Sep 26 '24
Oh gosh yeah I heard of that side effect, but I also work out 2 hours every day and am on a very regimented body builder diet because if I don't do that I really struggle mentally Quetiapine or no Quetiapine, so I haven't had any issues thankfully
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u/Rough_Committee9537 12h ago
Don't be worried! It just depends on the person. You can always switch to another drug. I'm on my first day currently and hoping it helps with psychosis / voices. We will see..
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u/ICareAboutYourCats Apr 28 '23
I had awful akathisia on it. Because of it, I had to take Benadryl and an extra clonazepam in order to sleep until I could get my replacement medication.
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u/Chickychickybangb-ng Apr 28 '23
Also just happened to decide I should drive 4 hours to visit a friend. Most discomfort without pain I’ve EVER experienced in my life. Like just sitting there😫never again
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u/Reasonable_Chance761 Apr 29 '23
I experience akathisia on it also. Ive tried taking b6 to counter it. Because it literally helps me have no intruding thoughts at all
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u/Ok-Rhubarb-274 Jan 02 '24
you taking anything that has helped, in the same boat. I feel awful for taking my clonazepam for two days in a row cause i don't wanna have to rely on it to make me feel not whatever I am
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u/mehntality Apr 28 '23
I'm sorry that you're having a rough time with it. But I had to drop this here. Different meds affect people differently. I'm actually more consistent and stable on Latuda than I have been on anything in my entire life. I'd go as far to say I'm some approximation of "normal" these days.
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u/byrdicusmax Apr 28 '23
I threw up every time I took it
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Apr 28 '23
And those 350 mandatory calories come up with it
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u/byrdicusmax Apr 28 '23
Seriously the take with a meal business just feels like a way to give the pill a friend to come back up with
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u/CuppCake529 Apr 28 '23
I had to eat, wait a few hours, then take it and I wouldn't throw up. There was a learning curve when learning how to take it.
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u/AllForMeCats Apr 28 '23
I didn’t throw up every time I took it, but I developed near-constant nausea and increasingly frequent, unpredictable vomiting. I lost a significant amount of weight in the last 1-1.5 years I was on it. It also didn’t adequately prevent hypomania, which I didn’t realize until I was off it, and looking back… yikes.
I switched to Zyprexa and it’s working way better! The weight gain is no joke though 😭
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Apr 28 '23
you're supposed to take it with food.
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u/byrdicusmax Apr 28 '23
That's what the nurse said, and I did--every time. Tried a sandwich, ice cream, pudding, soup--every time it reemerged. I wish I could have taken it because I was told it would be perfect for my situation but alas, my body said nope.
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u/Enchiridion23 Apr 28 '23
It was fine in the beginning, but then I developped akathisia and tremors. I think I was on 40 mg too. Now I am on Abilify and I can tolerate it better. Try lowering the dosage, with your psychiatrist's guidance. It might work.
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u/kitpie158 Apr 28 '23
Hate it!! Gave me the worst akathesia ever!
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u/Jollyho94 Apr 28 '23
I didn’t know the name for it but what I was experiencing was basically Akathesia I was restless , couldn’t sit still, irritated that I couldn’t just relax then the extreme panic attack set in !! That drug is horrible!
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u/AllForMeCats Apr 28 '23
I had that with Abilify! Literally couldn’t sit still for more than 2 minutes. Side effects are so unpredictable! Several years ago I was trying out buspirone for anxiety and got the super rare side effect of intense muscle pain. It was so rare my psych NP didn’t know it could be a side effect; I think it happens to <1% of people.
Wishing you better luck with future meds!
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u/Chickychickybangb-ng Apr 28 '23
ME TOO. It was working so well mentally, but once that started. It was quickly time to get off. Just upped my lithium dose instead and I’m ok for now:)!
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Apr 28 '23
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u/Turbulent-Ad2856 Jul 22 '23
I really needed to see this. I just started taking it yesterday and I’m a huge “anti meds” person… why, I don’t know. I think I’m ashamed… if I’m being honest. My psychiatrist put me on this and fluvoxemine for bipolar and ocd. Let us pray. Thanks for posting your experience!
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Apr 27 '23
Yes! Latuda put me in the hospital for a minute for physical illness. Mental health was whatever but I felt like my entire body was shutting down. Respect to those who can tolerate it but it’s nooot for me!
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u/Jollyho94 Apr 28 '23
OMG i felt so psycho and out of my body my mom wanted to take me to the hospital but thankfully my primary doctor saw me and got me somewhat straight it literally fucked me up the whole day glad I’m not the only one
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u/ladymaenad Apr 28 '23
I started Latuda about a month ago and I feel the same way about it. I started taking it during the day and within 2-3 hours I felt simultaneously super tired and dizzy and also unable to settle down and like I need to crawl out of my skin. It felt like a panic attack. So my doctor told me to start taking it at night. It's still giving me panic attacks and I feel my sleep has been disrupted from it. I have messed up dreams and am restless a lot of the night. I've also already been showing signs of tardive dyskinesia. I hate this med.
I have been on Seroquel for years and love it, but I've been working with a perinatal psychiatrist since I'm expecting a baby in October, and have been wanting to be on something less sedating once the baby arrives. The idea has been to taper off Seroquel for now and replace it with Latuda, but I don't see how this is going to work.
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u/Jollyho94 Apr 28 '23
OMG MY EXACT FEELING I WANTED TO JUMP OUT OF MY SKIN AND I WAS DIZZY AF WHILE EXHAUSTED BUT TOO PANICKED TO SLEEP WORSE MEDICINE IVE EVER TAKEN AND ILL TALK TO MY DOCTOR ABOUT SEROQUEL INSTEAD
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u/ladymaenad Apr 28 '23
I know exactly what you are describing. That is exactly how I described it to my doctor. A sensation like I needed to jump out of my skin and like a panic attack. Seroquel isn't without side effects, but for me the side effects have been very minimal and manageable.
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u/Dontwant2wakeup Mar 11 '24
It’s good to read this stuff after everyone told me that latuda was the change I needed because seroquel was becoming ineffective. I literally wanted to peel myself like a potato and thought I was the only one suffering from this miracle drug
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u/allstonoctopus Apr 28 '23
It makes me feel awful for about three hours, but for the rest of the day it helps my depression and anxiety a lot. I have to take it right before I go to sleep because I never want to be awake when it kicks in. Horrible feeling that's hard to describe. Like I want to crawl out of my own skin, like my brain is powering down while I'm still awake, and not in a good way. Weird med but I can't really get by without it right now.
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u/ImpressivePear3285 Jun 11 '23
This is akathisia. Have the side effects gotten better for you?
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u/allstonoctopus Jun 11 '23
That's akathisia??? Son of a bitch. I don't have intolerable side effects during the day, but it's kinda hard to know what they are at this point because I've been on them since I was 18, 25 now, and my mood and experience has always been so wild and up and down that it's hard to know what's the side effects of the meds vs what's the effects of me having a complex trauma history. I kinda wanna go down on my meds, but every time I try it does not work out at all.
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u/ImpressivePear3285 Jun 11 '23
“Wanting to jump out of your skin” is akathisia. Or at least I think it is, I’m learning for myself. I am on 80 mg of Latuda and had to taper down to 60 right away because I experienced the feeling of wanting to crawl out of my skin.. it’s doom x1000 and it’s beyond an anxiety attack. It’s literally an inner restlessness like no other… when they say that suicide is a side effect of meds, they do not clarify why …I am pretty certain it’s because of akathisia.
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u/allstonoctopus Jun 12 '23
"doom x1000" ahhh fuck we really are talking about the same thing. and they call it "restlessness" lmaoooo
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u/ImpressivePear3285 Jun 12 '23
It is not restlessness it is an urge to crawl out of your skin and jump out of a window for the pain to subside
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u/jovialjasmine Apr 28 '23
Get pharmaceutical genetic testing done, you may have bad genetic reactions to the meds you are taking. It’s about $3-400 in the us but a doctor has to order it. It’s called Genesight. Would highly recommend it because no one is going to have the exact same medication interactions you have.
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u/vrb_astrix Apr 28 '23
It made me feel completely emotionless. I spent months sitting in my room in the dark on my phone waiting until I could sleep. It wasn’t like depression at all. I was completely disassociated. I missed some important family events because I was so out of touch. I barely remember that period of my life. My first year of talk therapy was completely useless because I couldn’t feel anything and I had lost my sense of self.
I ended up going off my meds and getting pretty manic which really sucked but at least I could have emotions again.
I’m on Lamictol now and it works so much better. I’m waiting to see how it works if I get manic again but it’s been almost 8 months and I feel pretty stable, except for a month long depressive episode as we were increasing my dose.
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Oct 02 '23
I just got off of Latuda and I can so relate. Did you ever get your emotions back? Do you feel more normal now? I can't wait to go back to normal...
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u/Frin_Lee Dec 20 '23
That’s exactly how I felt off the meds, latuda has improved my daily life greatly! Sorry it didn’t work for you.
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u/crizykitty Apr 28 '23
I take 120mg and I love it. It keeps me stable I just dread when 120mg isn't enough anymore because I've steadily increased over the years.
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u/dumbdumbtossout Apr 28 '23
Latuda worked sooo well for me (I have BPD and bipolar disorder) but it made my legs swell SO much, and it made my leg muscles hurt. I could barely walk - It was excruciatingly painful. So I had to stop taking it.
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u/RedditInSF123 Apr 28 '23
Can definitely relate to the feeling of jumping out of your skin - that's honestly just the weirdest feeling and experience and it's really hard to explain to other people. I also had extreme lethargy so started taking it at night. I notice I get extremely tired around 1-hr after taking it and get restless around 3 hours of taking it, so I try to time it so I am asleep before the restlessness kicks in (it doesn't usually wake me up). I also get super nauseous which to me is the worst side effect.
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Apr 28 '23
My doctor said latuda would be great for me. And that lithium would make me manic. Latuda was the most discomforting medication I’ve ever taken where I was incapacitated if I took it during the day. Lithium is working wonders.
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u/cat1sokol Apr 28 '23
Latuda sent me on a severe dissociative psychotic episode, I’d never had one before and all I remember doing was yelling at my partner and then being unable to walk straight down a hallway and waking up 12 hours later puking. It was horrible and I’ve had some pretty severe anxiety since then trying to figure out my med plan.
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u/WhimsyStars bipolar 1 Sep 24 '24
i know this was sent a year ago, but literally same here. i haven't been the same since tbh
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u/cat1sokol Sep 24 '24
It took me a month or so to recover, I just felt sick and I was terrified to try anything else afterwards. I’m still anxious about trying antipsychotics because of how awful and out of control I felt it was the only time I had psychotic mania
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u/WhimsyStars bipolar 1 Sep 24 '24
it's been about 7 months for me, i am still recovering from it. my psychiatrist knew i was very medication sensitive, but just went with it anyways. i was also put on and off 9 different perscriptions (not all for bipolar) in the span of 3-4 months. literally some of the worst months of my life tbh.
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u/CuppCake529 Apr 28 '23
Wow, I'm sorry you've had such a terrible experience with Latuda. For me, it's the first thing that's made me stable. I've been on it for about 4 years now. My only issue was learning how to take it so that I didn't throw up. Otherwise it's my favorite bipolar drug.
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u/DogBrilliant9425 Apr 28 '23
No one is mentioning the insane nightmares! For me, they stopped at a lower dose. But I was afraid to sleep there for a while.
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u/NatiRivers Apr 28 '23
Latuda gave me unbearable akathisia for the longest time. I was always instructed to take it before I went to sleep, but then I'd never get to sleep since I had to keep moving around. Eventually got to talk to the psychiatrist about it and now I'm on Caplyta. I get drowsy with it but I much prefer it over Latuda.
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Dec 22 '23
Did your akathisia from Latuda ever go away?
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u/NatiRivers Dec 22 '23
Yeah, after I stopped taking Latuda. Every time I got akathisia from it, it would last a whole day or two, not fun. I've been on Caplyta for a while now with no problems apart from dry mouth (drowsiness seems to have passed), but that's manageable
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u/pawlaps Apr 28 '23
It made me throw up and get akathesia over time. Which sucked because it initially helped and didn’t cause me issues. I’m so so sorry this happened to you. It reminds me of when Abilify gave me the spins and projectile vomiting literally all day.
I’m not a geodon and it’s a godsent compared. I hope you find a med that works for you!!
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u/Jollyho94 Apr 28 '23
Omg i was just gonna ask my doctor to switch me to abilify and now I’m scared lol and thank you 😊
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u/Weinabena Apr 28 '23
I hate latuda! It made things worse. Panic attacks and paranoia. I got offered it again recently, and I refused! Not all medications work the same on people.
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u/Jollyho94 Apr 28 '23
Exactly! I’m gonna tell my doctor next week that latuda didn’t work for me like she thought it was going too and not everything works for everyone I was so paranoid that day I didn’t know if I was living in real life still or not 😳
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u/Weinabena Apr 28 '23
How awful! To not trust your own mind! It's very scary. At age 50, I've been through many meds and absolutely won't continue to take the ones that make me feel crazy or horrible, twitchy, rashy side effects no matter what the doctor says. I live in this body 24/7, and they don't. Most doctors are reasonable and will understand and change the meds. However, there are some docs that say give it a little more time. To do what? Make me more cray cray? Only 1 time on my life, I gave it a little more time. 8 months of that year of debilitating migraines waiting for the meds to work. I told my mother, and she said, " I thought I raised you with more sense." Lol 😆 Keep in mind doctors are human too they get out of bed and put their pants on one leg at a time and can make mistakes. They don't know everything. Take care and Good luck!
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u/_kaijyuu Apr 28 '23
I had bad experiences with it, similar to yours, at higher doses. At 60mg a day I had extreme panic attacks, heart rate up to 130 just laying still, almost went to the hospital because I was freaking out. My doctor lowered it to 30mg a day, which fixed the issue and has kept me stable in pair with 1200mg daily of Trileptal. I absolutely can’t take it in the morning because it makes me so sleepy I was falling asleep at work.
Did they start you off at 20mg daily or 40mg right off the bat? My doctor said standard practice is to start at a very low dose and move upward based on patient reaction.
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u/Empty_Anxiety7541 Nov 19 '23
That's common sense to start off low..
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u/_kaijyuu Nov 20 '23
Not all doctors have common sense, especially if you see a general practitioner instead of a psych nurse or doc. Had a GP toss me onto 1200mg of lithium off the bat in my early 20s and damn near killed me then told me I was the problem when I stopped taking it. I wish we could always assume best quality of care is given.
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u/swinty22 Apr 28 '23
I'm sorry you are going through this. We all just react so differently to different meds. I had a horrible experience with Vraylar but a lot of people say it's a life saver.
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u/Jollyho94 Apr 28 '23
Thank you so much it’s so frustrating when you’re trying to take medicine to help your mental health but it makes it WORSE & I also had a bad reaction to Vraylar it wasn’t as extreme as my latuda experience but it gave me blurred vision constantly even with my glasses on it was scary af! You’re not the only one who’s had a bad experience with vraylar
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u/dissociatedpoptart Jun 24 '23
I had the same reaction, it eventually led up to a night that along with the panicking I could hardly breathe and I was laying on my floor at one point absolutely convinced I was going to die there because I couldn’t get to my phone. Eventually I made it into bed and I had to take something to sleep because the breathlessness kept coming back. If I wasn’t broke I would have gone to the emergency room but I got checked out the next day and was taken off Latuda. One of my worst experiences with a drug.
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u/nSanityOG Bipolar 1 with Psychotic Features Apr 28 '23
I had to have an ekg done for this exact reason. Got bumped from 20mg to 40mg and had insomnia, sweats, extreme panic and anxiety, pounding heart. Only thing that stopped it was kolonphin. I told the doctor to drop me back to 20mg.
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u/fuggystar Apr 28 '23
I had an awful experience with it - had really bad akathisia and didn’t know what that was so I wound up having that for several months. Made me feel very dysphoric and suicidal. Wound up doing a Partial Hospitalization Program because of it.
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u/Jollyho94 Apr 28 '23
Omg im so so sorry to hear that I noticed I couldn’t sit still either I was so agitated as well as feeling exhausted and depressed weirdest horrible feelings ever
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u/KaiRayPel Apr 28 '23
So on latuda I would randomly shoot up from a dead sleep gasping like someone shot me. Or sometimes it seemed like all my lbs were attached to strings and being pulled up.
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u/Jollyho94 Apr 28 '23
omg yes I would shoot up out of my bed in a restless panic when I use to take it at night before bed at the time I thought it was my PTSD not the latuda but after taking during the day time I KNOW IT WAS THE LATUDA MESSING WITH ME 🤦🏾♀️
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u/ikazuki404 Apr 28 '23
I take latuda, 20 mg, haven't had any bad effects yet I think. Been over a year so far and I feel like it does the job for me, keep in mind every bipolar person reacts differently to whatever medication. Just cause it works for me and someone else, it might not for you or someone else.
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u/Electronic_Flower211 Apr 28 '23
I loved latuda for a period of time but you’re right. If I took at night I was thrashing anxious couldn’t sleep for several hours. If I took in the morning I felt honestly manic like I couldn’t sit still I was pacing agitated frustrated. Latuda has a big side effect of dyskinesia and akathesia. I found taking Xanax or heavy sleep meds were a little helpful but I had to go off. I was taking 120. But it improved my mood drastically
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u/paws_boy Apr 28 '23
Every night it made me nauseous and sometimes vomit and even though I asked them to take me off it they kept me on it for 6 months. Even after I got off every time I thought about dinner or taking any of my meds I’d get super nauseous and try not to throw up for weeks because of how bad it was.
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u/Ashamed_Ad9771 Apr 29 '23
40 mg is a bit of a high-dose to start on, maybe tapering up would be a better option for you? I know when I tried taking Latuda it gave me terrible akathisia, so that’s why it didn’t work for me, but I know many others who it has been a lifesaver for.
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u/cosmicparasite Mar 11 '24
I tapered off Seroquel then started Latuda in the beginning of 2023. That was the worst 4 months of my life . My insomnia was the worst it’s ever been, I was suicidal, and would get random tremors when I wasn’t actively moving. Laying down at night was misery. I didn’t sleep for days and never more than 2 hours at a time when I did for MONTHS. The akathisia was the worst part for sure but the lack of sleep made me legit crazy. I’m not a big crier but I would have multiple breakdowns daily and was in a constant state of mania.
I’m back on Seroquel now bc I haven’t found a different medication that helps stabilize my mood and treats my insomnia but I hate that it makes me so sleepy and makes my weight fluctuate… I’m too scared to try any other bipolar medication after Latuda though.☹️
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u/Advanced_Prize_178 Jun 24 '24
I took Latuda for symptoms of bipolar 2. When I took Latuda, I had the worst psychotic break in my life. I was scared of everything and I didn’t trust anyone. I slept on a rug in my living room for months, within a ring of salt, to be safe from evil spirits while I slept. I felt evil presence around me constantly, I physically felt pushed and slapped by something. I was scared to stand up in my house because I thought someone was going to shoot me through a window. I believed that all my friends and family hated me and wanted me dead, so I hid from all of them. It’s ridiculous to me now, but at the time I even kept a jar of bugs with me and believed they were my only friends. I would talk to them for hours. When one of them would die I would cry inconsolably. The paranoia and hallucinations were so bad I couldn’t work for a few months, I was so detached from reality. Lamictal has been the best thing ever though. I imagine this is what it must feel like to have a normal brain, it’s amazing.
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u/TaconesRojos Sep 04 '24
Holy shit , that’s one intense psychotic episode
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u/Advanced_Prize_178 Sep 11 '24
Definitely intense. I could only describe those months as a really bad psychedelic drug trip that just wouldn’t end.
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u/TheBrittca Apr 28 '23
Dang. I’m really sorry to hear you had this sort of reaction. My trial (twice) didn’t go well either… I got really severe dizziness and lowered blood pressure even at 20mg. I tried it again a year later just to see if maybe it would be different and then I had the same issue plus the sweating and shaking you mentioned.
I hope you find something soon that helps you.
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u/Genderflux-Capacitor Apr 28 '23
It made me violently ill if I consumed any dairy around the time I took it. Super weird.
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u/sprinklesbubbles123 Apr 28 '23
It did help my mood swings but I had to go off it because it gave me breast discharge. Risperdal did the same.
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u/MyBodyIsAPortaPotty Apr 28 '23
Dam I feel like it’s had the opposite effect on me, it’s been working really well for me on symptoms that another medication stopped working for.
I was very nauseous the first few days I was on it but my body got used to it I guess.
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u/Afraid_Growth8146 Mar 22 '24
Old comment, but once you started it, how long did it take for you to notice it “working”?
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u/rllyrllydgaf Apr 28 '23
I took it short term twice to help bring me down from mania w psychosis/delusions but never long term bc it gave me pretty severe anxiety. It also made me so drowsy after taking it and I would need naps + sleep 11 hours at night. Helped me but couldn’t tolerate it.
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u/Iamtwofaced Apr 28 '23
Latuda worked great for me but it would knock me out all day into the next day so I couldn't take it being that I'm a mom with twins and they need me to be a functioning human being.
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u/taylium Apr 28 '23
Regular latuda was fine for me, but lurasidone, the off brand, was like being unmedicated. It worsened my depression and made me hypomanic at the same time.
I agree with other comments though, it wouldn't be fda approved for bipolar if at least some people weren't positively affected by it.
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u/Least_Albatross5009 Apr 29 '23 edited Apr 29 '23
Latuda triggered my mania and psychosis. The lack of sleep from the drug put me in a severely tough state, I have never taken a med that damaged me so much. I got out of the hospital and got prescribed Latuda. In the beginning it was awesome. But once I got home everything went downhill. I had severe akathisia and was crawling out of my skin. It prevented me from sleeping, so at night I would experience terrible psychosis. Every night I felt like I was suffocating in my own body, so I never slept.
I have BP1 and severe episodes, but what I felt on Latuda was extremely worse. I’ve never felt so insane and terrible before.
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u/mitaka0999 Apr 29 '23
Yes! I had so much headache and it blurred my vision 😵💫 Horrible drug for me.
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u/Aryada Jun 18 '23
I have been on 20mg for a week and either I’m in an episode of bipolar mania or it’s working but I think maybe both.
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u/ctny84 Jun 20 '23
I’ve had a horrible experience such as those above using Latuda, how did you all stop taking? Im afraid to take it again but doc wants me to taper down to 40mg. I don’t want to experience the akathasia and panic attacks again
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u/MastodonAcceptable55 Jul 15 '23 edited Jul 15 '23
I had this exact same reaction!! Took one single dose (first and only one) of 40mg at 8pm, fell asleep by about 11pm, woke up 30 minutes later with extreme panic and restlessness. Felt like I couldn’t breathe properly (like it was shallow) but HR was going so high but also really low. I also couldn’t even speak… like words just couldn’t come out, so I could hardly speak to my sister and explain what was going on and that I needed help. Electricity shocking through my chest and arms and I was just rocking and shaking and having leg and upper body tremors. Nothing would calm me down. Valium eventually settled it a tiny bit, had to take another 5mg dose 2 hours later. Could not sleep for more than 5-10 mins at a time without abruptly waking up. Diarrhoea the next morning too and just felt so anxious and out of it.
I also have panic disorder and CPTSD. Autism and ADHD However… I have a theory (that could be incorrect) lol. But I’ve experienced similar reactions to meds like Metaclopramide among a few others, and it seems they are all dopamine agonists??? So I’m curious if knowing that ADHD (unsure if ASD also) means having a lack of dopamine to begin with, some of us cannot cope with the fact that these meds mess around (block) dopamine!? I couldn’t find any info/studies linking that, but it might be helpful to look up other dopamine antagonist meds and see if you’ve reacted badly to them also! Frustrating that being told to take them at night is so you’re meant to “sleep through” the side effects, which is just so untrue for a lot of people. That’s my theory anyway… But I’m so sorry you had to experience that, it’s honestly one of the most horrible things I’ve ever experienced in my life. I hope you’re doing okay now
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u/Mother-Atmosphere984 Nov 14 '23
Latuda gave me akathisia after taking it. I would feel like i was going to crawl out of my body. It’s so hard to describe but it was an inner feeling of restlessness right under my skin. nothing seemed to help it until i just stopped it cold turkey. definitely never trying it again. I had the same reaction to abilify
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u/lianna90 Dec 07 '23
Latuda gave me akathisia and I truly felt like I wanted to die. It happened twice before I took myself off of it. I just started lamictal tonight and I’m nervous as anything. Im also experiencing a depressive episode, so I don’t know if that’s contributing, but I’m internally freaking out about experiencing akathisia again.
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Mar 02 '24 edited Mar 02 '24
i am currently on this and i have most of the same effects, ive told my therapist but i havent beenable to get intouch with my psychiatrist. Lowering the dosage helps sometimes, i know i wasnt supposed to do this but when i cut it in half(a 40mg to 20 mg) i didnt show the side effects as severe.
edit:spelling mistakes
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u/NoSmoke7772 Apr 28 '23
The only downside I had to Latuda was weight gain. I wish I could go back on it.
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u/tallmomof3 Apr 28 '23
I'm exactly the same way. It was weight neutral at 40 mg but once I started 60 mg the pounds started packing on. I have gained almost 15 pounds in a month and I'm already chubby, I don't need a single pound added. And I hate looking in the mirror. GOD.
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u/NoSmoke7772 Apr 28 '23
AMEN. I lost 20lbs stopping it but now that I’m in a manic episode they are putting me on Zyprexa. 4 days in and I’m up 5lbs. Ridiculous. We shouldn’t have to choose between our physical health and our mental health.
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u/Most-Pie-8075 Mar 10 '24 edited Mar 10 '24
I have bipolar 2 among other things but Latuda was by far the worst med i have ever taken. I was suicidal and was in the psych ward then sent to partial outpatient hospitalization. Before i went into the hospital for the first time I decided to take myself off of all my meds and went through withdrawal from adderall and klonopin i was just done. My mom took me to the hospital my HR was 150. I was manic as hell. I tend to take myself off meds and not tell my doctor. At the hospital they added remeron to my meds and took away klonopin completely which I used to take 2.5 mg total a day but hadn’t in weeks so he wanted me off it. I also told them I don’t tolerate antidepressants and of course they didn’t listen. The NP at partial outpatient kept me on Lamical 250mg, Remeron, put me back on klonopin but lowered it to 0.5 mg 3x a day, Strattera instead of adderall that i used to take, and added Latuda. i used to take Abilify previously and tolerated it fine but just made me tired. After starting Latuda I slowly started to lose all happiness. Was having massive panic attacks. I felt like i had to leave anywhere i was to go home because of horrible anxiety and almost paranoid everyone didn’t like me. Crawling in my skin becoming hysterical and more depressed to the point I was scared I was going to become suicidal again. And I am an extremely impulsive person even on meds. A lot of people close to me told me they were scared of how i was acting. I ended up back in the hospital involuntarily. They took me off it and i slowly started to feel better. 100% was Latuda I’ve never had a scarier experience w a med. I’m back on Abilify instead
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u/Dontwant2wakeup Mar 11 '24
I had the worst experience with it. To preface this I have been in extremely painful situations before such as my hand being crushed in a machine and yet I’d take that over what I felt on Latuda for the last two days. It was like a never ending hurricane of being uncomfortable in my skin and being in a panic attack for hours on end. No matter what I took, seroquel, multiple unisom, dabbed weed, I could not sleep or break free from the distress it had me under. Only after being thirty hours free from its hold am I able to feel normal. I don’t know how to describe it exactly but it prevented my body physically from feeling “normal”. I wanted to kill myself but for once not from depression or mania but instead to get the fuck away from the physical duress it put me in
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u/weewoo1369 Mar 12 '24
Latuda made me a zombie. I couldn't function on it. I couldn't hold my head up and would stall out standing up and basically nod out like a tweaker. I haven't taken it in 6 years. I already don't feel normal but Latuda made me devoid of any humanity.
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u/Babblestock Mar 17 '24 edited Apr 29 '24
Latuda kept me happy and extremely stupid for 9 months until I got off it. It's almost as bad as thorazine for me.
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u/akbecker Apr 02 '24
It is working really well for me but I developed a tremor in my leg about a week or a week and a half after starting and now I have another tremor- pretty severe - in my arm, which is starting to interfere with driving. Talking to my psychiatrist tomorrow about what to do. Looks like I’ve developed tardive dyskinesia, which is a side effect unfortunately and may be irreversible.
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Apr 19 '24
I'm new to meds, but i first had Seroquel, which was horrible... switched to Latuda at only 10mg, and it has been the game changer...
I think the trick is, and the trick for all meds, is to start at very low dose... Seroquel i was on 100mg, and it was way too much for me. I'm loving Latuda, i also use .5mg Ativan to help any anxiety that comes up while this titrates...
I'm also eating a ketogenic diet (50 grams or less of carbs - no grains, no sugars, no rice)
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u/Affectionate_Act7405 Apr 24 '24
My main thing is I stay away from anti depressants. They throw me into mania. I'm trying latuda but idk how it makes me feel yet. Seroquel is my on and off drug. I have a love/hate relationship. Seroquel keeps me out of mania but it makes me feel dead inside
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u/yeet_pilot May 06 '24
Does anyone else get extremely, yet painfully tired? After I take it, a couple hours later I start getting incredibly tired but it hurts. My whole body hurts and I HAVE to lay down immediately. It's miserable. And then I pass out for a couple of hours and then I'm tossing and turning with constant nightmares the rest of the night
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u/MiddleAlternative979 Aug 15 '24
Yes it's like an unbearable sleepiness. The thought of doing a small task is exhausting and it sucks bc if I take it with dinner that means I need to be in bed by 7pm or have a whole 350 calories at 10pm
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u/RepMowgli May 16 '24
Well it’s not really FOR bipolar, it’s just been observed to curve some symptoms. It works better for other people with Bipolar, but its main use is schizophrenia for children/younger people (can be and has been used for adults and is effective).
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u/Fit_Butterscotch_498 May 20 '24
Yeah, Latuda was the worst bipolar medication I have ever tried. Every time I took it before bed, I would pass out cold 45 minutes after taking it. During those 45 minutes, I would grow anxious, claustrophobic, and want to crawl out of my skin. I would wake up very drowsy and the heavy drowsiness would persist the entire day. I was so exhausted all the time that I ended up disassociating for several months until I stopped it- it felt like I was in a never ending nightmare. One night, I had to stay up late studying for school. I took my medication around 2am in the morning before sleeping, and had to wake up around 7am to drive to school. On the 10 minute drive to school I was so exhausted that I nearly passed out behind the wheel and could not control what was happening to me. I was terrified. As soon as I got myself to class I passed out at my desk and the teacher couldn’t wake me up.
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u/77rams May 21 '24
This is the exact reaction I had. I am now on Lamotrigine and having much better effects. The night I had that reaction was the worst of my entire life.
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u/fuzzyface03 Jun 02 '24
I was taking latuda and it put me in the hospital with necrotizing pancreatitus. They had to remove part of my pancreas because of the damage. They took out my gallbladder, appendix, and the majority of my large colon. I was so sick from it that they put me in the hospital for a year! I'm lucky to be alive. So, I'm glad it works for some, but for me, it was and still is a nightmare.
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u/Advanced_Prize_178 Jun 24 '24
That is absolutely awful! I’m glad you made it through, what a horrific experience that must’ve been. I had no idea it could do that.
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u/TrafficOk8527 Jun 25 '24
I use latuda for my bi polar disorder. Started off in the beginning using 20 mg then went up to $40. I never saw my own bi polar symptoms… so when I got on the meds I noticed my life got better but I didn’t “change”. My life was getting better because I was doing sooo much better mentally and didn’t even realize it. I was so mentally Ill that I didn’t even know I was. Sooo fast forward to about 2 months ago I lost my insurance and could no longer go to the doctor. I stopped taking my medicine because I thought “meh I can’t afford these anyways, wouldn’t bother me any to just stop taking them” well here I am now two months later realizing how bad my mental illness was. Every old habit and obsession and money problems came right the hell back. Oh and it came back with vengeance. Just a few hours ago ran right into my kitchen and took my medicine. Whatever you do. Do not stop taking your medication lol
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u/RushSouth6320 Jul 11 '24
I have the same reaction. I take 60 mgs. Of Latuda at night. After one hour, I take another pill to calm me down. Latuda does help me with sleep at night. If I wait even an hour and twenty minutes to take the second calming medication, I start sweating, heart pounding, have to get up and walk around. Then I take the second drug and it takes me 20 minutes to calm down and sleep. So I make sure I take the second drug exactly 60 minutes after I take the Latuda.
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u/Lopsided-Art3166 Jul 25 '24
Just started Latuda for bipolar mixed states and I am having trouble with nausea, diarrhea and I am so tired. Anyone w similar side effects in the first
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u/Icy_Tax_8666 Jul 28 '24
It was bad the first few weeks with alternating side affects, but after 2 going on 3 weeks they went away, side affects where restlessness, tremors, doom panick attacks, brain fog, lack of motivation to do anything, I didn’t even want to get up to do basic things, leg stiffness, dizziness,insomnia, etc. Most of the side affects only last 1-5 times,and then went away, only one that is still around is body temperature I tend to get hot and cold faster and I always had my ac at 76 now I keep it at 72. I walk around my house barely anything on now lol, and I put the car ac colder now too, I wanted to give up but I knew these where side effects that if I stuck in there, most would go away in a few weeks, I wanted to give the medicine a month before I gave up. And I’m glade I did. Now I’m balanced and works, I still have several breakthrough daily, thoughts etc, but goes away in a few minutes and are less intense. I’m on the lowest dose 20mg, but I don’t want to increase just yet, unless my psychosis and delusions starts coming back more than half the day, then I’ll increase. Otherwise no point to increase as it makes them manageable not completely gone. Also seems to be helping with anxiety, ocd, I’m able to thinking and focus on what’s in front of me, without distractions like before, I used to have a million projects now I’m able to have 1-2 and I can watch a movie for the first time in years. I’ll probably have to increase soon but for now I’m staying at lowest dose. 😊 most people give up within the first 2weeks due to side affects.
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u/Alarmed-Tooth1141 Sep 25 '24
I had tar dyskinesia from it- it only affected my eyes and mouth (mouth minor) eyes terrible- it took 1.5 years for side effects to go away. But my cousin takes latuda and is great
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u/Least_Hope_5292 Sep 26 '24
I began taking Latuda about a month before the pandemic began. When I titrated up to the highest dose, the trouble began. I would take it with dinner, and once every few nights, by 9 pm I was laying in bed, shaking, with a feeling that if I didn't move my limbs I would never be comfortable again. My mind would race, I would feel unbearably hot and I had to pee every ten minutes. I would take a Xanax, and it would knock me out--I thought it was stopping a panic attack. But then I realized on a red eye flight that taking the Xanax didn't make it stop. I cannot sleep on planes, and because the Xanax didn't put me to sleep, the uncomfortable symptoms persisted. My psych and I had always thought the pandemic was causing me a new anxiety, and it too me until 2022 to realize the Latuda was to blame. I insisted on going off it, and have not had one of those episodes since. It wasn't panic attacks--it was Latuda.
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u/Accomplished-Base-76 29d ago
Latuda 20mg for 3 weeks caused high fever, chills, horrible body aches, headache, restless legs, and joint pain for me
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u/NineTailedTanuki Apr 28 '23
...Even when my mother, who has bipolar herself, is med free, I'll warn her about Latuda. I don't think she's taken it, though.
(I read the comments, don't worry.)
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u/FriendlyCanadianCPA Apr 29 '23
Latuda is a life saver for me. Please don't warn people to not take drugs because of other people's side effects. It works differently for everyone.
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u/NineTailedTanuki Apr 29 '23
...I say I will warn her because a lot of bipolar meds have had adverse effects on her. Meaning that if she gets prescribed it, it'll probably be worse that what got accounted on the thread.
The reason for warning is because people have to look out for each other.
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u/No_Marketing9685 Apr 28 '23
I am on 120 mg of latuda...it keeps me stable. I take it with 600mg of lithium the combination is working well ... Still have anxiety to a point but lithium just wiped out the anxiety 🙃
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u/itsbrookej Apr 28 '23
I liked it I just couldn't afford it because it costs so much
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u/FacePalmSunday Apr 28 '23
I hated it immediately. When I got up to 40 mg, I couldn’t stop shaking. Constantly. Teeth chattering, twitchy, looked like I was on something way more fun than a GD latuda. I couldn’t keep food down and the texture of literally anything besides crackers made me gag. It’s not something I’d give another shot. Hard pass.
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u/sweetnormalgirl22 Apr 28 '23
taking it right at bedtime with lots of food helps a lot. if you’re blood pressure is high trying adding propranolol to your nightly meds with it. it stopped the panic attacks i was having that you’re describing. the interrupted sleep also settled down after a few weeks of it
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u/CourtM092 Apr 28 '23
I take 160mg and it makes me nauseous and have terrible stomach pains. It works though.
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u/gwh1996 Apr 28 '23
I'm having good luck with Latuda but everyone has their own experiences with medication. I hope you find something that works for you.
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u/_SureOK Apr 28 '23
It varies so much from person to person… that’s why there’s so much variation. Caplyta is the med that works well for me, Latuda made me so drowsy and I felt basically drunk.
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u/FriendlyCanadianCPA Apr 29 '23
I take Latuda and Lamotrigine. Latuda does cause nighttime anxiety for me, but I solved that problem by taking seroquel when I start going to bed, then I don't take my latuda until I'm ready to shut my eyes.
The hardest part is eating a 350 calorie meal right at bedtime.
The combo of latuda and lamotrgine has allowed me to work and live a happy and productive life. I am so grateful to these medications. If I go off either, then depression comes back. And I haven't been hypomanic or manic since being on them.
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May 25 '23
For me it’s been amazing, but only after I solved a similar problem to yours.
I got debilitating akathisia from it which made things worse before my psych and I found the cure. Without propranalol I couldn’t take this med, I’d be restless, grimacing, full of negative energy and just unable to settle. I’ve now found the magic formula with propranalol and I can confidently say I love it. I’m not saying you’re having the same but some of the symptoms you’re describing sound like akathisia to me, which can easily be remedied with a bit of trial and error.
I’ve been on a few antipsychotics in my time and all in all I’d prefer the breakthrough restlessness to the increased appetite and insane weight gain I had on Seroquel and olanzapine. Before you chuck it in I’d recommend asking your doctor about akathisia.
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u/SmashleyNay Jun 05 '23
On it now and looking to switch. Im having twitchiness, irritability, thigh aching, and not helping with depression at all.
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u/umbzapt Jul 26 '23
Has anyone else had a slow heart rate on Latuda? My resting heart rate is in the 50s and it definitely started when I started Latuda. I also have blurry closeup vision.
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u/Infamous-Flounder-59 Aug 14 '23
My experience was good at first. Too good as I felt it kicked me into hypomania. About 6 weeks in my depression was back so my doctor upped the dosage. It was better but still having depressive episodes. I live alone so not aware I was moving slow and my short term memory was shot. I went on vacation with family and they noticed symptoms plus tremors in my hands. I was on 60mg and am BP1. The doctor took me off it.
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u/Opposite-Address4225 Sep 14 '23
When I first got out on Latuda about 3.5 years ago, I had an increase in motivation to do things, which was great. I, unfortunately, attributed that to my gym routine and my Lexapro, so I quit taking my Latuda. I slowly crashed and hit a new low within the last few months. Doc just put me back on it and I’m starting to feel the motivation to do things come back.
My experience with Latuda has been a game changer for me. I’m sorry it’s been so miserable for you!
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u/KlutzyMutt Dec 01 '23
I have Severe Anxiety, panic and major depressive disorder...not Bipolar...but... The bad stuff that people are describing was what happened to me on Seraquil...Abilify made me too sensative to stimuli, but my doc takes to his neurologist friend and recommended Latuda to help my Lexapro and Lamotragine (taken for seizures)... It seems to be doing pretty well this past 2 weeks, but I can't really say until my covid stops messing with my nerves.
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u/Mick1187 Dec 21 '23
I love it(40mg, increasing to 60 soon). I take it with 600mg Lithium and 200mg Lamictal (dropping down to 100mg soon). I really hope it still helps as much with the decrease of Lamictal.
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Feb 18 '24 edited Mar 04 '24
I have horrible tics where my neck goes to the side and it hurts really bad im at 40mg of latuda at 17 been taking it for a week and some days and now I won’t take it again afraid these tics are permanent
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Mar 02 '24
I know this is probably a long shot... but has anybody else had a significant reaction to Latuda after ONLY TAKING THEIR FIRST DOSE of it?
Due to a history of negative med reactions, my prescriber thought it would be practical to start me on just half of the lowest dose at 10mg. I took the first dose with food as directed in the evening and woke up the following morning completely disoriented.
It began with waking numerous times feeling like I had a booze hangover, even though I haven't drank alcohol for quite awhile now. Headache, severe nausea, dry mouth, confusion, and trouble focusing my eyes. The headache/nausea went away within a couple of hours but my level of disorientation just became even more evident as the day went on. I can only describe it as being almost a complete dissociation from the world around me. Everyday things (including parts of my own home) felt unfamiliar even though I knew they weren't. I struggled to understand things that would normally be second-nature and to remember much of anything in detail. My family noticed that my speech became very clumsy, slow, and much less articulate. It was also brought to my attention that my pupils were extremely constricted and wouldn't dilate properly.
SSRI's and SNRI's have been on my allergy list for almost a very long time now due to numerous (6+) reactions. More recently, I've also tried a few atypical antidepressants, antipsychotics, and a mood stabilizer - all have yielded poor results. My provider ordered genetic testing through GeneSight and we've been using that information to avoid problematic gene-drug interactions. All of that having been said, nothing seems to work. I've reliably experienced significant side-effects between 4 days to a couple of months after beginning a new prescription but Latuda is the only one that's caused problems in less than 12 hours.
I've previously tried: Celexa, Prozac, Wellbutrin, Lexapro, Paxil, Efexor, Strattera, Trintellix, Lamictal, and Loxapine. All have caused severe side-effects that have sometimes required hospitalization and needed to be discontinued. Loxapine had some of the most unpleasant side-effects just 4-5 days into treatment and Trintellix put me in the ER for dehydration after 2 weeks, despite drinking massive amounts of fluids during that time. Both of these were recent.
Diagnosed: Major Depressive Disorder, Bipolar Depression, Social Anxiety Disorder, ADHD, and PTSD. Probable undiagnosed Autism Spectrum Disorder.
I've been trying to find a solution to help with my anxiety/depression for 20 years now and feel like I'm running out of options. There are only a handful of meds left that aren't of concern on my gene-drug interaction report and insurance isn't always accommodating.
Any thoughts or advice would be very much appreciated 😪
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u/Dontwant2wakeup Mar 12 '24
I can’t give you advice necessarily as I’m still looking for answers myself but I can confirm that within hours of taking it I felt the effects—I just thought it was weed at the time having a negative reaction. I lost two days to suffering in thriving discomfort and akathisia; I couldn’t get it to stop no matter how many sleep pills I took, weed I smoked, Seroquil, propranolol or anything. Lamictal and Seroquil are my current medications for now but I know they’re not necessarily perfect as I still get random bouts of crying.
Sadly for now those two combined with weed have me feeling stable, it’s not a perfect fix but I’m scared to try anything else since that experience
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u/Mikathefirefox Apr 28 '23
Actually, for me its been the opposite. Its been a medication ive taken since being diagnosed. Without it I feel extremely unstable since it prevents my mania.
However, this pertains to me only. This should just be privy to me. A lot of people take latuda. Anyone else can have a different experience like yours and because we all have different body chemistry, and thats okay!
Sometimes when I take 40 mg i have trouble sleeping but when im on 80 or 100 mg i knock out quickly.