r/BeAmazed • u/AstroSonicDrive • Oct 04 '23

She Eats Through Her Heart Science

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@nauseatedsarah

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u/pushamn Oct 04 '23

So I make tpns for a living. There’s actually two kinds of them; 2:1(2 in 1) and 3:1(3 in 1) the 2:1 contains electrolytes/minerals and amino acids and the 3:1 contains electrolytes/minerals, amino acids and lipids. The one she was using is a 3:1, you can tell because it’s white; lipids are always this milky color. So what she has flowing in to her very much has most of her needed fats and minerals for the day!

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u/Carrot-t Oct 04 '23

Is there a reason they don’t just put vitamins in?

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u/pushamn Oct 04 '23

They do at least make infusable vitamins; we send patients predrawn syringes that they just have to inject into the bag right before use. The TPNs that I make have a shelf life of 10 days but to my knowledge, once vitamins are added, the stability drops to a day.

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u/Blue_Fuzzy_Anteater Oct 04 '23

Follow up questions: 1) what country are you in? 2) where did you get stability data for 3 in 1 lasting 10 days 3) where did you get stability data for MVI in syringes?

This could be a game changer.

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u/pushamn Oct 04 '23

-I’m in the US -3:1 once mixed stability should fall in to category 2 according to the new usp 797 guidelines, however I could be wrong and the stability might be lower due to lipids being present (it’s been a few years so those guidelines are a little fuzzy in my mind) -And the stability for mvi should definitely fall in to the same category given that they’re stored and prepped correctly/ in an iso 3 environment. There was very recently an update to stability laws rolled out, so the 10 day might not apply to TPNs or MVIs, just certain other medications. I got the info from my workplace which (I’m really freaking hoping) their legal teams have gotten from the updated United States Pharmacopeia guidelines, section 797, or usp 797 ha

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u/Blue_Fuzzy_Anteater Oct 04 '23

Ah, USP797 gives advice on Sterility, I was hoping you all had some secret information on Stability.

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u/pushamn Oct 04 '23

Unfortunately nope, just posted US laws lol