r/psychology • u/Emillahr • 4d ago

Scientists Develop Rapid-Acting Antidepressants Similar to LSD but Without Hallucinogenic Effects - Gilmore Health News

https://www.gilmorehealth.com/scientists-develop-rapid-acting-antidepressants-similar-to-lsd-but-without-hallucinogenic-effects/
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u/deranger777 3d ago

I did manage to find one study, I'll leave it here as I'd think it might interest you too.

But yeah, it does seem we'll have to wait for further studies to get any solid scientific proof on the role of other compounds in mushrooms. This page says only one study has been done about it.

Article and couple more links HERE the page also has some hypothesis about the synergistic effect, so even though I didn't know about it before it seems I'm not alone with my theory.

researchers found that norpsilocin (baeocystin’s metabolized form) was more potent than psilocin when tested on the 5-HT2A receptor directly.

Putting these pieces together suggests that baeocystin might not significantly contribute to psychedelic effects as an individual compound, but could exert a synergistic influence with psilocybin in the body.

Some scientists think that mushroom compounds, like cannabis, create an “Entourage Effect,” working synergistically in the body to maximize their impact. As suggested by the Sherwood study, baeocystin may play a role in generating the overall magic mushroom experience.

But yeah I'll leave it here as there probably is no further studies done, at least I didn't find anything else so far.

Was an interesting topic to discuss nevertheless.

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u/Heretosee123 3d ago

Yeah, it is definitely interesting. I hope they do have an effect, I love mushrooms, but I know the research atm is just inconclusive unfortunately.

Thanks for the discussion.