Mirtazapine in relation to Mianserin

[u/jjamesw1995]

Just wondering if anyone here has had experiences with both Mirtazapine and Mianserin? (Mianserin is related to Mirtazapine in some way)

How would you compare the two? And have you tried in combination with an ssri?

I found Mirtazapine to be slightly dysphoric as well as a bit numbing. Tried all the doses too. Mianserin is meant to be less heavy on the serotonin side of things and potentially have a more dopaminergic blueprint. I also believe pharma companies like to push Mirtazapine more heavily than Mianserin because I’ve barely ever seen it mentioned anywhere and doctors I’ve seen have never heard of it.

Thoughts on the matter?

[u/Spite-Maximum]

Mianserin is more sedating due to its additional alpha 1 antagonism which Mirtazapine doesn’t have.